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When using Trenbolone, it should be recognized that the "hard" and a unique side effects result from the fact that it is a 19-nor progestational compound. Studies have shown that 19-nor anabolic steroids tend to exhibit a binding affinity for the progesterone receptors in the body. Trenbolone has notably very strong binding affinity (much stronger than nandrolone) for progesterone receptor. Progestogen side effects are almost identical to estrogenic side effects, and these include: severe suppression of endogenous production of testosterone, gynecomastia and water retention (which is not the case with Trenbolone).It was found that the activity of progestogens is closely related to the activity of estrogen in the body.