Several types of tumors, like testicular tumors and pituitary tumors, can impact hormone production. If your body isn’t making enough testosterone, or is making too much estrogen, this ratio imbalance can lead to gynecomastia.
"The other tumor effect that can happen with some lung tumors and testicular tumors is to make a hormone called HCG," explains Dr. Anawalt. "What HCG does is it acts like the hormone LH to stimulate testosterone production from the testicles, but it also stimulates more conversion of testosterone to estrogen."
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For decades many athletes who use anabolic steroids have supplemented with the SERM Tamoxifen ( Nolvadex ) to combat such issues. Nolva, as it is commonly known acts to block the estrogen from binding to the receptors; it does not reduce estrogen as is commonly thought by many who take it. However, while this is a solid prevention measure, for many it is not enough and only an aromatase inhibitor will do. An aromatase inhibitor will actually reduce the amount of estrogen in the body and bind it what’s left. While perhaps not completely accurate but to give you an idea, for the prevention of Gynecomastia when steroids are present look at Nolva like Aspirin and aromatase inhibitors like morphine; far stronger. The two most common aromatase inhibitors that will in most cases get the job done include Anastrozole ( Arimidex ) and Femara ( Letrozole .)