Non steroid responsive asthma

The exact etiopathogenesis of SRMA is unknown ( Tipold 2000 ). Activated T cells have been demonstrated in dogs with SRMA, indicating potential contact with an antigenic stimulus; however, no bacterial or viral agents have been identified to date ( Tipold and others 1996 ). A Th2-mediated immune response is most likely, based on the presence of high CD4:CD8a ratios and a high proportion of B cells in peripheral blood and CSF. A Th2-mediated immune response is further supported by the expression of low levels of Th1-response-related cytokines (IL-2, IFN-γ) and upregulation of Th2 cytokines (IL-4) in blood and CSF in dogs with the acute form of SRMA ( Schwartz and others in press ). This Th2-mediated immune response leads to an upregulation of the humoral immune response and excessive IgA production ( Schwartz and others 2008b ).

Methotrexate is given weekly as an intramuscular injection of 15 to 25 mg. Side effects are rare and include leukopenia and hypersensitivity interstitial pneumonitis. Hepatic fibrosis is the most severe potential sequela of long-term therapy. Patients with concomitant alcohol abuse and/or morbid obesity are more likely to develop hepatic fibrosis and therefore should not be treated with methotrexate. It is prudent to obtain a baseline chest radiograph and to monitor complete blood count, liver function and renal function every two weeks until the patient is receiving oral therapy, and every one to three months thereafter. Before methotrexate therapy is initiated, the risks of treatment and the possible need for a liver biopsy should be discussed with the patient.

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  • Citation tools Download this article to citation manager Cohen Steven P , Hanling Steven , Bicket Mark C , White Ronald L , Veizi Elias , Kurihara Connie et al. Epidural steroid injections compared with gabapentin for lumbosacral radicular pain: multicenter randomized double blind comparative efficacy study BMJ 2015; 350 :h1748
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    In order to prescribe ASIT, allergens to which a dog is hypersensitive need to be identified through allergy testing. Both intradermal and serum tests detect allergens. A positive allergy test indicates the presence of excessive amounts of IgE, and a positive result may be associated with clinical allergy or subclinical hypersensitivity. The significance of a positive result can only be ascertained once all other causes for the dermatitis have been ruled out. Also, a positive result should be for an allergen present in high quantities at the time of year that the individual patient has exacerbations of skin disease. Thus, the dermatologist will review patient history prior to selection of allergens for immunotherapy.

    Non steroid responsive asthma

    non steroid responsive asthma

    In order to prescribe ASIT, allergens to which a dog is hypersensitive need to be identified through allergy testing. Both intradermal and serum tests detect allergens. A positive allergy test indicates the presence of excessive amounts of IgE, and a positive result may be associated with clinical allergy or subclinical hypersensitivity. The significance of a positive result can only be ascertained once all other causes for the dermatitis have been ruled out. Also, a positive result should be for an allergen present in high quantities at the time of year that the individual patient has exacerbations of skin disease. Thus, the dermatologist will review patient history prior to selection of allergens for immunotherapy.

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