Which made Canseco’s second benefactor — Mike Wallace — all the more important. John Hamlin, a producer at 60 Minutes , had gotten a tip about Canseco’s book from a friend at another network. (The friend couldn’t act on it because his employer was a Major League Baseball rights holder.) Hamlin began calling baseball people and confirming the details. Almost no one would talk on the record, but they suggested that Canseco’s account was true. One of the few allegations Hamlin couldn’t verify was Canseco’s insistence that Roger Clemens was juicing.
Because steroids are lipophilic, they diffuse easily through the cell membranes, and therefore have a very large distribution volume. In their target tissues, steroids are concentrated by an uptake mechanism which relies on their binding to intracellular proteins (or " receptors ", see below). High concentration of steroids are also found in adipose tissue, although this is not a target for hormone action. In the human male, adipose tissue contains aromatase activity, and seems to be the main source of androgen-derived estrogens found in the circulation. But most of the peripheral metabolism occurs in the liver and to some extent in the kidneys, which are the major sites of hormone inactivation and elimination, or catabolism (see below).
Some people who abuse steroids to boost muscle size have experienced physical or sexual abuse. In one series of interviews with male weightlifters, 25 percent who abused steroids reported memories of childhood physical or sexual abuse. Similarly, female weightlifters who had been raped were found to be twice as likely to report use of anabolic steroids or another purported musclebuilding drug, compared with those who had not been raped. Moreover, almost all of those who had been raped reported that they markedly increased their bodybuilding activities after the attack. They believed that being bigger and stronger would discourage further attacks because men would find them either intimidating or unattractive.