So, back to the sympathy that is not offered. I feel both family and physician should be proactive in bringing up the subject, talking about the effects of this disease in that person’s life, and making sure that depression is not significant. A good start is to say “you know, I bet you don’t get much sympathy for this problem”. The management of nasal polyps may not have the adrenaline of the emergency department, and it won’t save a life. It’s about long-term management with every support needed to maintain quality of life. And that’s often harder to do than a lot of acute medicine.
It is likely that much of the mechanism for the anti-allergic and anti-inflammatory effects of mometasone furoate lies in its ability to inhibit the release of mediators of allergic reactions. Mometasone furoate significantly inhibits the release of leukotrienes from leucocytes of allergic patients. In cell culture, mometasone furoate demonstrated high potency in inhibition of synthesis and release of IL-1, IL-5, IL-6 and TNFα; it is also a potent inhibitor of leukotriene production. In addition, it is an extremely potent inhibitor of the production of the Th2 cytokines, IL-4 and IL-5, from human CD4+ T-cells.