Many hormones and their structural and functional analogs are used as medication . The most commonly prescribed hormones are estrogens and progestogens (as methods of hormonal contraception and as HRT ),  thyroxine (as levothyroxine , for hypothyroidism ) and steroids (for autoimmune diseases and several respiratory disorders ). Insulin is used by many diabetics . Local preparations for use in otolaryngology often contain pharmacologic equivalents of adrenaline , while steroid and vitamin D creams are used extensively in dermatological practice.
Madrigal Pharmaceuticals, Inc. (Nasdaq: MDGL) is a clinical-stage biopharmaceutical company pursuing novel therapeutics that target a specific thyroid hormone receptor pathway in the liver, which is a key regulatory mechanism common to a spectrum of cardio-metabolic and fatty liver diseases with high unmet medical need. The company’s lead candidate, MGL-3196, is a first-in-class, orally administered, small-molecule, liver-directed, thyroid hormone receptor (THR) β-selective agonist in clinical development for the treatment of non-alcoholic steatohepatitis (NASH) and familial dyslipidemias/hypercholesterolemias, among other related indications.