Matrix Assisted Laser Desorption Ionization (MALDI) -MALDI is a method of ionization in which the sample is bombarded with a laser. The sample is typically mixed with a matrix that absorbs the laser radiation and transfer a proton to the sample. Some small mass samples can be ionized without matrix, but this is typically called laser desorption. The laser is always pulsed, and typically in a vacuum. In addition, MALDI mostly forms singularly charged ions. This means MALDI is mostly performed on specially built time-of-flight instruments. One major application of MALDI besides simple analysis is imaging mass spectrometry.
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