Gonadal steroid hormones and the hypothalamic-pituitary-adrenal axis

Endocrinology 2016 : 6th International Conference on Endocrinology will be held during December 05-07, 2016 at Dallas, USA. Endocrinology 2016 will focus on the theme “New recommendations and practical approaches in the treatment of endocrinal disorders”. The studies are more connected with the topics Diabetic Disorders and Treatment, Current Advances in Endocrinology & Metabolism, Thyroid Gland and its Disorders, Reproductive Endocrinology, Energy Balance and Obesity, Treatment and Diagnosis of Endocrine Diseases, Surgery. 

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

There are also many synthetic sex steroids. Synthetic androgens are often referred to as anabolic steroids . Synthetic estrogens and progestins are used in methods of hormonal contraception . Ethinylestradiol is a semi-synthetic estrogen. Specific compounds that have partial agonist activity for steroid receptors , and therefore act in part like natural steroid hormones, are in use in medical conditions that require treatment with steroid in one cell type, but where systemic effects of the particular steroid in the entire organism are only desirable within certain limits. [6]

Gonadal steroid hormones and the hypothalamic-pituitary-adrenal axis

gonadal steroid hormones and the hypothalamic-pituitary-adrenal axis

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gonadal steroid hormones and the hypothalamic-pituitary-adrenal axisgonadal steroid hormones and the hypothalamic-pituitary-adrenal axisgonadal steroid hormones and the hypothalamic-pituitary-adrenal axisgonadal steroid hormones and the hypothalamic-pituitary-adrenal axisgonadal steroid hormones and the hypothalamic-pituitary-adrenal axis

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