Gluconeogenesis anabolic reaction

In human beings, PEP carboxykinase is equally distributed in both location and thus either oxaloacetate or PEP formed inside the matrix of mitochondria must be transported out into the cytosol. The transport of oxaloacetate requires shuttle system. It is converted either into malate catalyzed by malate dehydrogenase or into aspartate catalyzed by aspartate aminotransferase in the matrix before being transported out of the matrix into the cytosol through their respective transporter. In the cytosol, malate or aspartate is converted back into the oxaloacetate catalyzed by cytosolic isoenzymes and then oxaloacetate is converted into the phosphoenolpyruvate catalyzed by PEP carboxykinase.

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Gluconeogenesis anabolic reaction

gluconeogenesis anabolic reaction

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