Pharmacokinetic studies with Peridex indicate approximately 30% of the active ingredient, chlorhexidine gluconate, is retained in the oral cavity following rinsing. This retained drug is slowly released into the oral fluids. Studies conducted on human subjects and animals demonstrate chlorhexidine gluconate is poorly absorbed from the gastrointestinal tract . The mean plasma level of chlorhexidine gluconate reached a peak of mcg/g in humans 30 minutes after they ingested a 300- mg dose of the drug. Detectable levels of chlorhexidine gluconate were not present in the plasma of these subjects 12 hours after the compound was administered. Excretion of chlorhexidine gluconate occurred primarily through the feces (~90%). Less than 1% of the chlorhexidine gluconate ingested by these subjects was excreted in the urine.
PerioGard ® therapy should be initiated directly following a dental prophylaxis. Patients using PerioGard ® should be reevaluated and given a thorough prophylaxis at intervals no longer than six months. Recommended use is twice daily oral rinsing for 30 seconds, morning and evening after toothbrushing. Usual dosage is ½ fl. oz. (marked on dosage cup) of undiluted PerioGard ® . Patients should be instructed not to rinse with water or other mouthwashes, brush teeth, or eat immediately after using PerioGard ® . PerioGard ® is not intended for ingestion and should be expectorated after rinsing.