Alpha lipoic acid steroidology

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Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats.
Rom J Morphol Embryol. 2009.
The aim of the present study was to investigate the effect of alpha lipoic acid supplementation on plasma lipid, oxidative stress and vascular changes in diabetic rats. It is concluded that alpha lipoic acid has the potential in preventing the alteration of vascular morphology in diabetic rats probably through the improvement of blood sugar status and lipid cholesterol issues as well as its antioxidant activities.

Although the body can synthesize LA, it can also be absorbed from the diet. Dietary supplementation in doses from 200–600 mg are likely to provide up to 1000 times the amount available from a regular diet. Gastrointestinal absorption is variable and decreases with the use of food. It is therefore recommended that dietary LA be taken 30–60 minutes before or at least 120 minutes after a meal. Maximum blood levels of LA are achieved 30–60 minutes after dietary supplementation, and it is thought to be largely metabolized in the liver. [65]

To examine the effect of short- vs. long-term ALA supplementation on the liver, “black 6” mice (C57BL6/J, a common laboratory mouse strain) were treated with 20mg/kg ALA for 4 or 74 weeks. [88] After the treatment period, mice were euthanized followed by liver tissue analysis for lipid and cholesterol metabolism. Short- and long-term ALA supplementation caused an increase in β-oxidation and decreased lipogenesis. In contrast, both short and long term ALA treatment increased liver cholesterol content by 70% and 110%, respectively, and increased triglyceride levels, inducing systemic triglyceridemia. Moreover, in spite of the fact that short-term ALA treatment decreased lipogenic gene expression, it also caused fat accumulation in the liver. Long-term ALA treated mice showed a worse phenotype, with extensive fat accumulation leading to hepatic steatosis and extensive liver damage. [88]

Alpha lipoic acid steroidology

alpha lipoic acid steroidology

To examine the effect of short- vs. long-term ALA supplementation on the liver, “black 6” mice (C57BL6/J, a common laboratory mouse strain) were treated with 20mg/kg ALA for 4 or 74 weeks. [88] After the treatment period, mice were euthanized followed by liver tissue analysis for lipid and cholesterol metabolism. Short- and long-term ALA supplementation caused an increase in β-oxidation and decreased lipogenesis. In contrast, both short and long term ALA treatment increased liver cholesterol content by 70% and 110%, respectively, and increased triglyceride levels, inducing systemic triglyceridemia. Moreover, in spite of the fact that short-term ALA treatment decreased lipogenic gene expression, it also caused fat accumulation in the liver. Long-term ALA treated mice showed a worse phenotype, with extensive fat accumulation leading to hepatic steatosis and extensive liver damage. [88]

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